Notes from a Life Spent in Healthcare

Notes from a Life Spent in Healthcare

Roseola infantum

introduction

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Will Taylor
May 25, 2026
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Roseola is not a “vaccine preventable” illness, but I include it along with a discussion of measles & chickenpox as another common childhood febrile exanthem.

Roseola may be known as Sixth disease, a classification of febrile exanthems including

  • First disease - measles

  • Second disease - scarlet fever

  • Fourth disease - considered by some to represent staphylococcal scalded skin syndrome, and by others to be a nonexistent disease entity and misdiagnosis of scarlet fever or rubella, dropped from medical textbooks in the 1960’s and only rarely used for medical trivia purposes

  • Fifth disease - erythema infectiosum, “slapped cheek syndrome,” most commonly referred to as Fifth disease

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